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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCL1 All Species: 10
Human Site: S150 Identified Species: 27.5
UniProt: Q07820 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q07820 NP_068779.1 350 37337 S150 L L E L V G E S G N N T S T D
Chimpanzee Pan troglodytes XP_513776 350 37318 S150 L L E L V G E S G N N T S T D
Rhesus Macaque Macaca mulatta XP_001102283 350 37185 S150 L L E L V G E S G N S P S T D
Dog Lupus familis XP_545888 237 26870 L73 D C E F G Y T L A L A Q D Y V
Cat Felis silvestris
Mouse Mus musculus P97287 331 35199 A131 L L E R V S E A A K S S G A D
Rat Rattus norvegicus Q9Z1P3 330 35196 A130 L L E R V S E A A K S S G A D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001233735 124 13778
Frog Xenopus laevis NP_001131055 275 30376 Y109 Q Q L I L A F Y R V Y S G E E
Zebra Danio Brachydanio rerio NP_571674 255 28643 Q91 E L E R D T R Q L L L D F Y R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.2 97.1 21.7 N.A. 77.1 78.5 N.A. N.A. 26 34.5 30 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 98.2 98.8 34.5 N.A. 84 83.4 N.A. N.A. 30.2 48.2 44 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 86.6 6.6 N.A. 40 40 N.A. N.A. 0 0 13.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 93.3 6.6 N.A. 60 60 N.A. N.A. 0 26.6 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 12 0 23 34 0 12 0 0 23 0 % A
% Cys: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 12 0 0 0 12 0 0 0 0 0 0 12 12 0 56 % D
% Glu: 12 0 78 0 0 0 56 0 0 0 0 0 0 12 12 % E
% Phe: 0 0 0 12 0 0 12 0 0 0 0 0 12 0 0 % F
% Gly: 0 0 0 0 12 34 0 0 34 0 0 0 34 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 12 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 23 0 0 0 0 0 % K
% Leu: 56 67 12 34 12 0 0 12 12 23 12 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 34 23 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % P
% Gln: 12 12 0 0 0 0 0 12 0 0 0 12 0 0 0 % Q
% Arg: 0 0 0 34 0 0 12 0 12 0 0 0 0 0 12 % R
% Ser: 0 0 0 0 0 23 0 34 0 0 34 34 34 0 0 % S
% Thr: 0 0 0 0 0 12 12 0 0 0 0 23 0 34 0 % T
% Val: 0 0 0 0 56 0 0 0 0 12 0 0 0 0 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 12 0 12 0 0 12 0 0 23 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _